Potassium, magniysberegayuschy diuretic. It is a competitive antagonist of aldosterone for influencing the distal nephron (competes for binding sites on the cytoplasmic protein receptors, reduces the synthesis permeases in aldosterone-sensitive portion of the collecting ducts and distal tubules), increases the excretion of Na + , Cl – and water and reduce the excretion of K + and urea, reduces titratable acidity of urine. Increased diuresis causes a hypotensive effect, which is unstable. The hypotensive effect is not dependent on the level of renin in the blood and plasma does not occur in normal blood pressure.
The diuretic effect is seen on the 2-5 day of treatment.
Testimony of Aldactone
Edema in chronic heart failure, cirrhosis (especially in the simultaneous presence of hypokalemia and hyperaldosteronism), in the nephrotic syndrome.
Swelling in the II and III trimester of pregnancy.
Hypertension, including aldosteronprodutsiruyuschey with adrenal adenoma (in combination therapy).
Primary aldosteronism. Aldosteronprodutsiruyuschaya adrenal adenoma (long-term maintenance therapy with contraindications to surgery or in the case of refusal from it). Diagnosis hyperaldosteronism.
Hypokalemia and its prevention in the treatment of saluretikami.
polycystic ovarian syndrome, premenstrual syndrome.
Dosing regimen of Aldactone
Set individually depending on the severity of violations of water-electrolyte metabolism and hormonal status.
When edema – 100-200 mg / day (at least – 300 mg / day) in 2-3 doses (usually in combination with “loop” and / or thiazide diuretic) daily for 14-21 days. Dose correction should be performed based on the values in plasma potassium concentration. If necessary, repeat every 10-14 days. When expressed hyperaldosteronism and reduced potassium content in plasma – 300 mg / day in 2-3 doses.
From the digestive system: nausea, vomiting, abdominal pain, gastritis, ulcers and bleeding in the gastrointestinal tract, intestinal colic, diarrhea or constipation.
CNS: dizziness, drowsiness, lethargy, headache, lethargy, ataxia.
Metabolism: increasing concentrations of urea, hypercreatininemia, hyperuricemia, impaired water-salt exchange and AAR (hypochloraemic metabolic acidosis or alkalosis).
From hemopoiesis system: megaloblastoz, agranulocytosis, thrombocytopenia.
From endocrine system: long-term use – gynecomastia, erectile dysfunction in men; women – dysmenorrhea, amenorrhea, metrorrhagia, menopause, hirsutism, deepening of voice, breast tenderness, breast carcinoma.
Allergic reactions: urticaria, makulo-papular and erythematous rash, drug fever, itching.
Other: muscle cramps, reduced potency.