Tretizen – a drug used in dermatology practice, which relates to a group of drugs, retinoids. The tool has dermotropic systemic action and can be used both internally and externally (topically). Furthermore, with appropriate indications the drug is used rectally.
Effect of Tretizen
Tretizen has antiinflammatory, antidandruff, sebostaticheskim, keratomoduliruyuschim and immunomodulatory effects, which occur when the system used topically. In addition, the drug increases the regenerative processes in the skin. The mechanism of the pharmacological action of the drug based on its ability to have a positive effect on the composition of sebum, reducing its production and to facilitate selection of the sebaceous glands, as well as eliminate the inflammatory process observed around glands in acne disorders.
Medicament in the form of capsules applied orally or rectally in acne is not amenable to other treatments, and in severe forms of acne such as conglobata, nodulocystic and acne with a high risk of scarring. Accutane is used to treat acne. Tretizen ointment is intended for topical use and is used in the treatment of perioral dermatitis , acne vulgaris, rosacea and seborrheic dermatitis.
According to the instructions, Tretizen capsules should be taken with food. The daily dose may be used in one or in several stages. Initial dose Tretizen Accutane and Roaccutane for intake of 0.5 grams per day. For a limited period of time the drug may be assigned to a maximum daily dose which is determined based on the rate of 1 mg / kg body weight. Supportive Tretizen daily dose in the form of capsules ranged from 0.1 to 1 mg per 1 kilogram of body weight. The duration of treatment is 16 weeks. After 8 days after it is assigned a second course of treatment with Accutane. For rectal use daily dose is set based on the rate of 0.5-1 mg / kg body weight. The introduction should be carried out in the supine position, once a day at bedtime. Duration of treatment is from 8 to 12 weeks. Between treatments are kept for a period of 1-2 months intervals. Tretizen ointment is used topically. It is applied to the affected skin areas twice a day. Duration of treatment using the dosage forms of the drug can be from 4 to 6 weeks.