Anastrover is a non-steroidal antiestrogenic drug.
- The main active substance is anastrozole.
- Form release – tablets, in a package of 25 pcs. On 1 mg / tab.
The drug is a highly selective non-steroidal aromatase inhibitor of the third generation. For medical purposes, it is used in women during menopause: taking Anastrover in a daily dosage of 1 μg reduces the level of estradiol by 80% – 98%. At higher dosages, the drug has androgenic and progestagenic activity, without affecting the production of aldosterone and cortisol, does not require the use of corticosteroids as a substitute. In comparison with aminoglungiimide, Anastrover has a longer half-life, and when used in small doses, prevents feminization. The half-life of the active substance varies from 40 to 50 hours. However, approximately 10% of the dose used goes with urine within 72 hours (including excreted and metabolites). The main metabolite Anastrover is Triazol, which does not have anti-aromatase activity.
How to take Anastrover
The course it lasts from 10 to 14 days and involves taking the drug at a dosage of 1 milligram per day. The active substance quickly enters the blood. If you take it on an empty stomach, the maximum concentration is observed after about 2 hours. While eating at the same time, the absorption rate decreases, but the amount of substance that enters the blood (ie bioavailability) remains unchanged. Approximately one week after the start of the drug, an equilibrium concentration in the blood is established. The course of the drug is sometimes accompanied by thinning of the hair, dryness of the mucous membrane of the urogenital zone, rash, diarrhea, vomiting, impaired liver function.