Proscalpin – synthetic drug, which is intended for the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness. The drug is an inhibitor of 5.alpha.-reductase type II. 5.alpha.-reductase – an enzyme responsible for the conversion of testosterone to dihydrotestosterone (DHT). It is a synthetic 4-azasteroid compound. Good lowers levels of DHT in the blood and prostate tissue. The systematic (IUPAC) name: N- (1,1-dimethylethyl) -3-oxo- (5alpha, 17beta) -4-aza-androst-1-ene-17-carboxylic acid, the formula of C23H36N2O2, molecular weight 372.549 g / mol .
Inhibitor 5-alpha reductase – the enzyme which converts testosterone to dihydrotestosterone, a more active. Reduces the concentration of DHT in the blood and the prostate tissue. It inhibits the stimulatory effect of dihydrotestosterone on the development of benign prostatic hyperplasia.
Proscalpin affects the decrease in size of the prostate, improves urine flow and reduces the symptoms that are associated with benign prostatic hypertrophy. In order to reduce the clinical signs of the disease may require several months of treatment.
Side effects of Proscalpin
Among the side effects of Proscalpin is the following: impotence (1.1 – 18.5%), excessive ejaculation (7.2%), reduced volume of an ejaculate (0.9 – 2.8%), sexual dysfunction (2.5% ), gynecomastia (2.2%), erectile dysfunction (1.3%), ejaculation disorder (1.2%) and pain in the testicles. Cessation of side effects observed in men who discontinued treatment, and the majority of men who have continued.
The manufacturer also reported cases of persistent erectile dysfunction, despite the discontinuation of the drug. In December 2010, Merck added depression to the list of side effects of the drug. In November 1997, the FDA declined to approve Propecia is a drug for the treatment of male pattern baldness. Without disputing its effectiveness, the members of the Committee expressed concerns about the probability of occurrence of long-term side effects on sexual function and it is likely that even the ability to reproduce. It is connected with the data to lower levels of ejaculate.
Despite official investigations, there is a site propeciahelp.com, dedicated only to the side effects of Proscalpin. It positions itself as an international organization of men who suffer from persistent sexual, mental and physical side effects caused by the drug Proscalpin (Propecia, Proscar and generics), used to treat male pattern baldness.