Description

Modafin – analeptic is used for the treatment of sleepiness associated with narcolepsy .

Office for Quality Control of Food and Drug US drugs (FDA) approved Modafin also for treatment of sleep disorders associated with shift work shifts (SWSD, Engl. Shift work sleep disorder ) and sleepiness associated with obstructive sleep apnea . European Medicines Agency , however, recommends limiting new prescription of medicines containing Modafin, only cases of narcolepsy, in connection with the risk of neuropsychiatric and skin and allergic side effects. At the same time, as these side effects are often observed in the first two weeks of the drug, it is used as intended, made earlier, not limited.

Indications and dosing regimen

In addition to these indications Modafin is approved in some countries, government regulators and for the treatment of cases of idiopathic hypersomnia (pathological daytime sleepiness, the causes of which are not precisely diagnosed).

For the treatment of hypersomnia associated with narcolepsy and obstructive sleep apnea recommended single taking the drug in the morning at a dose of 200 mg of , although there is evidence of clinical tests, according to which the double application (morning and noon), 200 mg more efficiently . A single reception in a dose of 400 mg does not significantly increase efficiency compared with a dosage of 200 mg of.

In the treatment of sleepiness associated with shift work shifts, it is recommended single receiving 200 mg. The drug for 1 hour before the change, a good effect is also achieved with a single application at a dose of 300 mg of.

In all cases, the daily dosage should not exceed 400 mg ; taking the drug is not recommended during the second half of the day, as Modafin slowly excreted ( half-life 12-15 hours), and can interfere with normal night’s sleep. In general, dosing recommendations range from 100 to 400 mg per day, in 1-2 Hour.

Side effects of Modafin

Among the common side effects Modafin found:

• Backache
• Headache
• Nausea
• Sense of anxiety
• Nasal congestion
• Diarrhea
• Feeling anxious
• Dizziness
• dyspeptic disorders
• Insomnia

Modafin may have an adverse effect on the action of hormonal contraceptive that lasts for months after discontinuation of the drug.