It inhibits reabsorption of sodium and chloride ions mainly in thick ascending part of Henle segment loops. Furosemide has a strong diuretic, natriuretic, hlorureticheskoe action. In addition, it increases the excretion of potassium ions, calcium and magnesium.
In heart failure in 20 minutes leads to a reduction of preload on the heart. Maximum hemodynamic effects achieved by the second hour of the drug, due to decreased tone of the venous vessels decreasing blood volume and interstitial fluid. It has a hypotensive effect due to increased excretion of sodium chloride, reducing the reaction on the vascular smooth muscles and vasoconstrictor effects by decreasing circulating blood volume.
Dosing and Administration
Taken orally. The dosage depends on the course and severity of the disease.
Adults. When edema of cardiac, renal or hepatic origin:
- moderately condition: ½-1 tablet per day,
- a serious condition: 2-3 tablets per day in 1 or 2 divided doses, or 3-4 tablets per day in 2 divided doses.
When high blood pressure in patients with chronic renal failure: in combination with other antihypertensive agents (antagonists of the renin-angiotensin system), the recommended usual dose of 20 – 120 mg per day in one or two steps.
Side effect of Frusenex
With the cardiovascular system: hypotension, orthostatic hypotension, collapse, tachycardia, arrhythmia.
From the nervous system: dizziness, headache, muscle weakness, leg cramps (tetany), paresthesia, lethargy, weakness, weakness, lethargy, drowsiness, confusion.
From the senses: visual and hearing impairment.
From the digestive system: anorexia, dry mouth, thirst, nausea, vomiting, diarrhea, constipation, cholestatic jaundice, pancreatitis aggravation.
With the genitourinary system: oliguria, acute urinary retention (benign prostatic hyperplasia), interstitial nephritis, hematuria, impotence.
Allergic reactions: purpura, urticaria, exfoliative dermatitis, erythema multiforme, vasculitis, necrotizing vasculitis, cutaneous itching, chills, fever, photosensitivity, anaphylactic shock.
From the side of hematopoiesis: leukopenia, thrombocytopenia, agranulocytosis, aplastic anemia.
From the water-electrolyte metabolism: hypovolemia, dehydration (the risk of thrombosis and embolism), hypokalemia, hyponatremia, chloropenia, hypocalcemia, hypomagnesemia, metabolic alkalosis.
Metabolic disorders: hyperglycemia, hypercholesterolemia, hyperuricaemia, glycosuria.